Figure 3 Genomic organization of PCV1 member of the type species of the genus Circovirus and CAV member of the type species of the genus Gyrovirus. ORFs are shown in open boxes, the direction of transcription is indicated by triangles. Transcripts are indicated by arrows, splice processes by dotted lines. (a) PCV1, the species type of the genus Circovirus, is shown. The ambisense genomic organization is outlined, that is, both strands of the replicative form are coding for proteins. Therefore, the two major genes Rep and Cap are divergently transcribed. Between the start points of Rep and Cap, the origin of viral replication is located. This element is drawn to a larger scale, displaying its characteristic features, a putative hairpin, and adjacently located repeats. An arrow indicates the position where Rep and Rep' restrict the replicative intermediate to initiate the replication.(b) CAV is a member of the type species of the genus Gyrovirus. Its genome is of the 'negative-sense' type, that is, the viral strand does not encode genetic information, it has to be converted into a dsDNA version, from which one polycistronic mRNA is produced. Splice processes have not been observed.
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