Varicose Veins No More
The relation between plasma endothelin-1 levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy in patients with Type 2 diabetes mellitus. Journal of diabetes and its complications, Vol. 15, No. 3, (May-June 2001), pp. (150-157), ISSN 1056-8727 Allain, H., Ramelet, A. A., Polard, E. & Bentue-Ferrer, D. (2004). Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids. Drug Safety, Vol. 27, No. 9, (August 2004), pp. (649-660), ISSN 0114-5916 Almarsson, O., Bourghol Hickey, M., Peterson, M. L., Zaworotko, M. J., Moulton, B. & (2008). Effects of calcium dobesilate and diosmin-hesperidin on apoptosis of venous wall in primary varicose veins. Vasa, Vol. 37, No. 3, (August 2008), pp. (233240), ISSN 0301-1526
It is now well established that early mobilization after childbirth is extremely important. Once the mother has recovered from the physical rigours of her labour, she should be encouraged to mobilize as soon as possible. The physiotherapist has an important role to play in returning the patient to normal health during the puerperium and limb exercises will be particularly important to encourage venous flow in the leg veins of any mother who has been immobilized in bed for any reason. Exercises to the abdominal and pelvic floor muscles are most valuable in restoring normal tone which may have been lost during pregnancy.
The vascular type of EDS (the former EDS type IV) is inherited as an autosomal dominant trait. It deserves special attention because its natural history and prognosis are different from those of the other subtypes. The typical clinical features of vascular EDS comprise a thin, translucent skin with a prominent venous pattern over the chest, the abdomen, and the extremities, increased bruising and bleeding tendency, and proneness to sudden rupture of blood vessels, internal organs, or the gravid uterus. Patients often have a characteristic facial appearance with large prominent eyes, small, pinched nose, small lips, and lobeless ears. Hypermobility is usually limited to the small joints of the hands. Other features include acrogeria, which is characterized by an aged appearance of the extremities, particularly the hands, tendon or muscle rupture, talipes equinovarus, early-onset varicose veins, arteriovenous, carotid-cavernous sinus fistula, pneumothorax or pneumohemothorax, and...
The role of platelets in the recruitment of monocytes and neutrophils to sites of vascular injury has long been recognized (Palabrica et al., 1992). The appearance of circulating LPAs is a dynamic process involving initial formation, vascular adhesion, potential sequestration to elements of the reticuloendothelial system, leukocyte activation, and LPA disaggregation via granulocyte proteinases (Gardiner et al., 2001). Circulating LPAs are increased in stable coronary artery disease (Furman et al., 1998), unstable angina (Ott et al., 1996), acute myocardial infarction (Furman et al., 2001 Michel-son et al., 2001), chronic venous insufficiency (Powell et al., 1999), and during cardiopulmonary bypass (Rinder et al., 1992). Circulating LPAs are also increased after coronary angioplasty, with a greater magnitude in patients experiencing late clinical events (Mickel-son et al., 1996).
Treatment for varicose veins is aimed at improving blood flow, reducing injury, and reducing venous pressure. Pharmacologic treatment is not indicated for varicose veins. To give support and promote venous return, physicians recommend wearing elastic stockings. If the varicosities are moderately severe, the physician may recommend antiem-bolism stockings or elastic bandages or, in severe cases, custom-fitted heavy-weight stockings with graduated pressure. When obesity is a factor, the patient is placed on a weight loss regimen. Experts also recommend that the patient stop smoking to prevent vasoconstriction of the vessels. A nonsurgical treatment is the use of sclerotherapy for varicose and spider veins. Sclerother-apy is palliative, not curative, and is often done for cosmetic reasons after surgical intervention. A sclerosing agent, such as sodium tetradecyl sulfate (Sotradecol), hypertonic saline, aethoxysclerol, or hyperosmolar salt-sugar solution, is injected into the...
Since apoptosis is closely linked with oxidation stress some aspects of anti-apoptic effects of calcium dobesilate were mentioned above in section 3.1. In a clinical study, the influence of calcium dobesilate to apoptosis of varicose veins in comparison with diosmin-hesperidin combination was investigated. Patients were treated either with calcium dobesilate or with diosmin-hesperidin six weeks prior to the surgical removal of the particular varicose vein. Tissue samples obtained from such veins of 56 patients were immunohistochemically stained with antibodies of anti-bcl-2 and anti-bax thus aimed at anti-apoptic (bcl-2) and pro-apoptic (bax) proteins. Significant differences in the presence of bcl-2 protein expression between the untreated patient group and the group treated with calcium dobesilate suggest that calcium dobesilate could be of benefit in treatment of vascular disorders by down-regulating apoptosis (Iriz et al., 2008). On the other hand, calcium dobesilate is capable to...
Recently, ALK-1 signaling has been demonstrated to have a role in arterialization and remodeling of arteries so that the arterioles rather than the venules are the primary vessels affected by the loss of an ALK-1 allele. Thus, contrary to the current view of HHT as a venous disease, the arterioles rather than the venules are the primary vessels affected by the loss of an ALK-1 allele. 9
(Picris echioides) In the Gironde district of France, they used to say that to cure a prick made by the bristles of this plant (if the identification is correct), one had to get up and cut a head of the same plant, and throw it behind one, without looking round (Sebillot). The leaf of Bristly Ox-tongue is used as a vegetable in southern Europe (Watt & Breyer-Brandwijk), and was cooked in England as a potherb in medieval times (Harvey). Binding the roots to the affected part in varicose veins was recommended as a cure at one time (see Tusser).
The root had other, more genuine, uses, for it served as a vermifuge. In the 19th century, oil of fern, made from this plant, could be bought to do the job (C P Johnson). The root was apparently marketed in the 18th century by a Madame Noufleen as a secret nostrum , for the cure of tapeworm. After he had paid a lot of money to buy it, Louis XV and his physicians discovered that it had been used ever since Galen's time (Paris). But, though used quite a lot in folk medicine, the roots are poisonous, and can even be fatal (Tampion). Perhaps that is why the dried leaves are used in Ireland for the purpose (Maloney). Although the root is occasionally used in tincture in homeopathic medicine, to treat septic wounds, ulcers and varicose veins, the chief use these days is in veterinary practice, for expelling tapeworms (Wickham).
There are a group of leechdoms involving MUGWORT to relieve sore feet, some dating from Anglo-Saxon times, in the version of Apuleius. One, for example, simply required the patient to take the wort, and pound it with lard, lay it to the feet (Cockayne). The Physicians of Myddfai claimed that for weariness of walking. Drink an eggshell of the juice of mugwort, and it will remove your weariness . Just carrying mugwort would do, for there is a Scottish belief that travellers who carried it would not tire (Beith). In Somerset, an ointment used to be made from MALLOW roots and unsalted lard, equally efficacious for varicose veins, they say (Tongue. 1965).
Into a necklace, as a charm to ward off rheumatism. They had to be gathered by children who had never suffered from the ailment (Porter. 1974). Some kind of horse chestnut decoction was drunk in Essex for lumbago, spoken of there as rheumatism (Newman & Wilson). Elsewhere, including Spain (H W Howes), it is piles that is reckoned to be cured or prevented by carrying them around (W B Johnson Tongue Fogel), and that is interesting, because it is known that extracts of horse chestnut are rich in Vitamin K, and so is useful in treating circulatory disorders like piles, varicose veins and chilblains (Conway). A fluid extract made from the nuts is also used to protect the skin from the harmful effects of the sun (Schauenberg & Paris).
Gerard was quite enthusiastic about the virtues of mallow leaves. They are good, he says, against bee or wasp stings, even the stingings of Scorpions , and if a man be first anointed with the leaves stamped with a little oile, he shal not be stung at all . One prescription from the Welsh text known as the Physicians of Myddfai, is for piles. It required the mallow to be boiled in wheat ale or in spring water. It is reported from Norfolk that children used to chew the fruits as a laxative (V G Hatfield. 1994). According to Somerset practice, varicose veins could be treated with an ointment made from mallow roots and unsalted lard, a treatment equally useful for sore feet (Tongue. 1965). The mucilage of the plant was, and probably still
The operation begins with an incision in the medial aspect of the thigh. Electrical cutting has the advantage that bleeding from varicose veins hardly occurs. The first muscle encountered is the gracilis, which is best freed half way up the upper leg by encircling the muscle with the finger. By pulling the gra-cilis toward the operator, the peripheral arteries and veins become visible and are cut after coagulation. The gracilis is then freed in the distal direction toward the tendon. The sartorius muscle covers this tendon. The tendon is freed in the direction of its insertion in the tuberositas tibiae. It is not necessary to go up all the way to the insertion, but the tendon can be cut 5 cm from the transition of muscle into tendon. The free gracilis tendon is grasped with a clamp and pulled toward the operator. Now it is easy to free the proximal part of the gracilis from its adhesions.
Hyperemesis gravidarum is more likely and severe cases may respond to steroid therapy or odansetron. All the minor complications of pregnancy such as backache, oedema, varicose veins, reflux, haemorrhoids etc. are also increased, both as a result of the physical effects of greater uterine size and also of greater placental hormone production. Gestational diabetes is increased in most studies.
A varicocele is a collection of dilated veins within the scrotum that look like varicose veins. It lessens a man's fertility by producing a slightly higher temperature in the testicles. A varicocele occurs in about 15 percent of all men and accounts for as much as 40 percent of male infertility problems.
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