Lactase
Some enzymes are employed as human digestive aids to replace or increase endogenous digestive enzymatic activities. Lactase and pancreatic enzyme replacement therapies are two such examples. The enzyme P-D-galactoside-galactohydrolase (EC 3.2.1.23), commonly known as P-galactosidase or lactase, hydrolyzes lactose, forming glucose and galactose 165 . Lactose, or milk sugar, is a disaccharide found in the milk of most mammals. Lactose is digested in vivo in the gastrointestinal tract by...
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Time (h for uric acid, d for creatinine, calcium, and phosphorus) Time (h for uric acid, d for creatinine, calcium, and phosphorus) FIGURE 8.6 Creatinine, calcium, phosphorus, and uric acid concentration after rasburicase treatment. hyperuricemia avoids strong alkalinization. A high urine pH is associated with decreased phosphate excretion, which can favor the precipitation of calcium-phosphate salts in the renal tubules, a cause of renal failure 46 . By reintroducing an enzyme present in most...
Thrombolytic Therapy in Acute Myocardial Infarction
The beneficial effect of thrombolytic therapy in the treatment of acute myocardial infarction (AMI) is now well established 13-15 . Use of thrombolytic agents has become a standard emergency treatment in such situations to the extent that globally, such drugs are administered to over 500,000 patients each year. It has been estimated that three times that number could potentially benefit from such therapy 5,16 . Although effective, these products achieve complete reperfusion in, on an average,...
Enzymes as Digestive Aids
An array of products, that contain supplemental digestive enzymes are currently in the market. Some of these preparations exhibit a single enzyme activity aimed at degrading a specific dietary substance, while others exhibit multiple enzymatic activities for the degradation of various dietary components. These supplemental enzymes can be used to complement normal digestion, or to provide an additional digestive capacity. Supplemental digestive enzymes are frequently depolymerases that act on...
References
Kreuder, V., et al., Isolation, characterization and crystallization of deoxyribonuclease-I from bovine and rat parotid-gland and its interaction with rabbit skeletal-muscle actin, Eur. J. Biochem., 139, 389-400, 1984. 2. Shiokawa, D. and Tanuma, S., Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis, Biochemistry, 40, 143-152, 2001. 3. Evans, C.J. and Aguilera, R.J., DNase II Genes, enzymes and function, Gene, 322, 1-15, 2003. 4. Nadano, D.,...
