Dopaminergic system

Multiple etiologies likely impact the dopamine system in RLS. The primary evidence for this comes from use of dopaminergic agents over the past 20 years. Most RLS symptoms (and PLMS) respond to treatment with dopaminergic agents, and, conversely, the use of dopamine receptor antagonists exacerbates the RLS symptoms. However, a clear understanding of any defect in the metabolism or signaling in the dopamine system remains elusive. Post-mortem and imaging studies have not provided clear evidence of dysfunction in the dopamine system. The results of SPECT and PET studies are inconclusive or conflict with one another (for overview see also [34] and [35]).

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