Sleep Disorders

The reciprocal interaction model

Sleep Apnea Depiction

McCarley and Hobson proposed the reciprocal interaction model to explain the transitions into and out of REM sleep states, described by the Lotka-Volterra equations, derived from population models of predator prey interaction 136 . The limit cycle model, an update of the reciprocal interaction model, incorporated circadian and local GABAergic influences on REM sleep regulation 118,137 . As reviewed in Figure 2.5, select cholinergic neurons of LDT PPT increase firing prior to and during REM...