The reciprocal interaction model

McCarley and Hobson proposed the reciprocal interaction model to explain the transitions into and out of REM sleep states, described by the Lotka-Volterra equations, derived from population models of predator prey interaction 136 . The limit cycle model, an update of the reciprocal interaction model, incorporated circadian and local GABAergic influences on REM sleep regulation 118,137 . As reviewed in Figure 2.5, select cholinergic neurons of LDT PPT increase firing prior to and during REM...