Scope

Secondary structure formation at interfaces is not limited to a specific class offoldamers, any more than their behavior in solution (see Part 1 of this book). The conformational behavior of peptides at interfaces has extensively been studied for several decades, especially in monolayers at the air-water interface, and more recently in self-assembled monolayers (SAMs) of peptides at solid-liquid inter-

faces [6-11]. Remarkably, only a few studies deal with other types of foldamers. In this chapter, we will therefore limit ourselves to representative, relevant examples of peptide-based systems, and focus on secondary structure formation in monolayers of nonpeptide foldamers.

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