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Receptors for Hydrophobic Small Molecules

Hydrophobic small molecules were the targets of the foldamers developed by Moore et al. [26]. The tendency of aromatic rings to pack together through p-stacking interactions, preventing their exposure to a polar environment, was used in the design of a helical foldamer with a hydrophobic interior (see Chapter 3). This scaffold was based on an oligomer of m-phenylene ethynylene units (9, Fig. 7.6a) which had been shown to undergo a transition from a random coil in

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