Hybridization of foldamers not only leads to beautiful structures but actually can serve specific functions, such as information storage and transfer, but only if the hybridization is based on selective interactions. The design of artificial systems with specific and selective folding and hybridization properties remains an interesting and challenging goal for the chemical community. These artificial model systems will help us to better understand Nature and her elegant use of foldamers and their intermolecular interactions in many different applications. The more the underlying molecular principles are understood, the more sophisticated the deliberate use of artificial systems will be. This however requires a sound knowledge of noncovalent interactions, their strength and solvent dependence as well as their specificity and directionality as has been shown above for several examples. There is still a lot to learn despite all the progress that has been achieved in this area in the last few years. We will definitely see even more beautiful and intellectually challenging self-assembling foldamers with surprising properties and interesting applications in the future.


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