Oooc oc

Donahue's syndrome, progeroid aspects, 1:2 Donor insemination, 4:24 Donors blood, 1:83

gametes, privacy of, 4:28 organ, primates as, 4:142 tissue, legal concerns, 3:3-4 transplant, defined, 4:139 Dopamine

ADHD and, 1:39-41, 1:41 neurotransmitter systems, 1:5 Dopamine transporter (DAT) gene, 1:41

Dosage compensation, defined, 3:81 The Double Helix (J. Watson), 4:173 Double-helix DNA model, 1:216-218, 1:218, 2:50, 2:51, 3:118-119

disrupted by mutagens, 3:88, 3:94

distorted by transcription factors,

4:112, 4:115 distortion, repairing, 3:114 right-handed helix, 1:217 unwinding in DNA replication,

4:12-16 of Watson and Crick, 1:62, 1:192-193, 1:251, 1:252, 3:105, 4:172

DoubleTwist, bioinformatics, 2:124 Down, J. Langdon, 1:256 Down syndrome, 1:256-258

association with leukemia, 4:155 average IQ, 1:79 chromosomal basis, 1:79, 1:256-257, 3:29, 3:97, 3:110, 3:111, 3:164 clinical features, 1:3, 1:256,

1:257, 3:110 cytogenetic analysis, 1:257 history, 1:119, 1:256 mosaic, 1:257

prenatal genetic testing, 1:258 progeroid aspects, 1:2-3 senescence, 1:3 statistics, 1:75 translocation, 1:257 trisomy 21, 1:257, 3:29 Down syndrome, prenatal genetic testing, 2:97 DRD2 mice, 1:5 Drosophila. See Fruit flies Drug dependence and birth defects, 1:77, 1:81 defined, 1:4

genetic components, 3:214 See also Addiction

Drugs (medications)

acceptable toxicity, 4:171 Ames test, 1:20-21 biopharmaceuticals, 2:125, 4:129 and birth defects, 1:80, 1:206 chemotherapy, 3:146, 4:74 combinatorial chemistry to synthesize, 1:175, 1:176-177 developing new, 2:121,

2:124-125, 3:206 estrogen replacement, 1:90 fertility, 4:19, 4:21-22, 4:28 high-throughput screening tools,

2:149-150 how they work, 2:149, 3:206, 4:44 and hyperpigmentation of iris, 2:33

immunosuppressive, 4:141 pharmaceutical scientist role,

3:142-144 poor and ultrarapid metabolizers,

3:144-145 side effects, preventing, 2:118-120, 2:122, 3:144-146, 4:22

signal transduction targets, 4:91 See also Antibiotic resistance; Antibiotics; Pharmacogenetics and pharmacogenomics Drugs (medications), for specific diseases

Alzheimer's disease, 1:181 cancer, 1:97, 1:153, 1:170 familial hypercholesterolemia, 2:57

hemophilia, 2:145 HIV/AIDS, 2:150-151,

2:155-156, 4:41 muscular dystrophies, 3:87 SCID, 2:81

sickle-cell disease, 2:138 Tay-Sachs disease, 4:102 viruses, 4:171 DSM-IV (Diagnostic and Statistical

Manual), 1:4, 3:213 DsRNA. See RNA, double-stranded Duchenne de Boulogne, 3:84 Dunker population, inbreeding coefficient, 2:190 Dunnigan-type lipodystrophy, 3:125 Dupont company, Genesis 3000

sequencer, 1:44 Duty of candor, for patents, 3:138 Dwarfism achondroplasia, 1:75-76, 2:82 prenatal genetic testing, 3:186 as quantitative trait, 4:1 skeletal dysplasias, 2:130-132

Dyskeratosis congenita, progeroid aspects, 1:2 Dystrophia myotonica. See Muscular dystrophy, myotonic Dystrophin gene, 2:77-78, 3:84-85, 3:100

E. coli bacterium. See Escherichia coli E2F family transcription factors,

1:106, 1:107 Ear wax consistency, 2:192 Earlobes, free, 2:191 Ears, hairy, 2:192 Ecological (sympatric) speciation, 4:93

Ecology. See Conservation biology, genetic approaches Ecosystem, defined, 1:59, 4:130 Ectopic expression, defined, 2:74 Ectopic pregnancies, 4:22 Edman degradation technique, 3:197 Edman, Pehr, 3:197 EDTA (ethylenediaminetetraacetic acid), 3:221 Educators, 2:1-3

genetic counselors as, 2:88-90,

2:91-92 medical role, 2:90 EGFR gene (Epidermal Growth

Factor Receptor), 1:95 Egg donation, assisted reproduction,

4:24, 4:28 Eggs chromosomal aberrations, 1:121 developmental processes,

2:34-35, 3:29 enucleated, cloned organisms,

1:158, 1:162-164 haplodiploidy, 2:113 as haploid, 2:113, 2:115, 3:24,

3:60, 3:163 human, size, 1:108 meiosis and, 1:115, 2:33-34,

3:24-29, 3:60, 3:75 microassisted fertilization, 4:22 mRNA stability, 4:51 mtDNA in, 2:197, 3:51 mutations, 2:192, 3:99 zona pellucida, 2:34, 2:35 See also Fertilization Eigsti, O.J., 3:165 Electron microscopy, 4:164-165 Electron transport chain (ETC) coding, mitochondrial vs. nuclear genomes, 3:52-53, 3:52 mitochondrial role, 1:111, 2:194, 3:41-42, 3:51-53, 3:52

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