Leading Strands and Lagging Strands

The coordinated synthesis of the two daughter strands posed an important problem in DNA replication. The two parental strands of DNA run in opposite directions, one from the 5' to the 3' end, and the other from the 3' to the 5 ' end. However, all known DNA polymerases catalyze DNA synthesis in only one direction, from the 5' to the 3' end, adding nucleotides only to the 3 ' end of the growing chain. The daughter strands, if they were both synthesized continuously, would have to be synthesized in opposite direc-

0 0

Post a comment