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Tools, 1 56 Knudson, Alfred Jr., 3 131 Koch, Christof, 1 194 Koonin, Eugene, 1 143 Kosambi, Damodar, 3 13 Kosambi map functions, 3 13 Kossel, Albrecht, 1 249 K-ras gene, and colon cancer, defects, 3 42, 3 43, 3 44 described, 1 111 Kremer bodies. See PML bodies Kuru disease, cause, 3 189 L929 cancer cells, 4 104-105 La Quinta High School, tuberculosis, 1 26 Laboratory information management systems, 1 54 Laboratory technicians, 3 1-3, 3 2 automated sequencing by, 1 43-45, 3 1 microbiologists as,...

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Rhabdoviruses are helical viruses and include the virus that causes rabies and vesicular stomatitis virus (VSV), a common laboratory virus. The lipid-containing envelope is embedded with glycoprotein (G) spikes. A layer of a matrix protein (M) forms a bridge between G and the nucleocapsid proteins (N). Also included in the virion are several molecules of the RNA-dependent RNA polymerase (Large or L protein) and its cofactor, the phosphoprotein (P). The genes for these proteins are arranged as...

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Mutation detection procedures, 3 92-93 newborns, 2 98-99, 3 42-43, 3 44 patent issues, 3 137 PCR contamination concerns, 3 158 presymptomatic, 2 100, 2 100-101 presymptomatic, children, 2 100-101 procedures, 2 102 public health role, 3 218 symptomatic, 2 99 See also Population screening Prenatal diagnosis Genetic testing, ethical issues, 2 101-106 CLIA standards, 3 218 clinical geneticist role, 1 149-150 eugenics concerns, 3 177-178, 4 29-30 genetic counselor role, 2 92, 2 102-104, 2 105...

Gamete Intrafallopian Transfer

An alternative to IVF and intrauterine embryo transfer is gamete intrafal-lopian transfer (GIFT), introduced more than twenty years ago. In this procedure, the egg and sperm are collected as they would be for IVF procedures. However, instead of allowing fertilization to take place in a culture dish, the egg and sperm are transferred surgically into the woman's fallopian tube. This allows fertilization to occur in the fallopian tube, just as occurs in a natural pregnancy. The transfer can only...

Twin Studies and Concordance

Insight into such questions can be gleaned by several types of studies that compare twins. Comparison of MZ twins reared apart is one type of study but is hampered by the extreme rarity of such twin pairs. Another type of study, comparing MZ twins to DZ twins, is more commonly done, because there are many hundreds of thousands of such twin pairs worldwide. Data on twins have been collected by numerous research groups who have created large and growing databases (registries) that can be mined...

Retroviruses and Cancer

Retroviruses are among several types of viruses that can induce cancer in the host organism. So-called slowly transforming viruses are exemplified by human T-lymphotropic virus (HTLV), which causes leukemia (a type of blood cancer) in humans. These viruses induce malignancy by a process called insertional mutagenesis. The initial event is thought to be retroviral integration near, and subsequent activation of, a cellular oncogene (c-onc). Examples of c-onc include genes for growth factors,...