Conclusions

We have illustrated the developments of several recent advances in acute stroke treatment and secondary stroke prevention. Clearly, the ability to effectively treat a patient having an acute stroke and reverse the neurological deficit can be dramatic and rewarding. The use of IV tPA has empowered physicians when they encounter eligible stroke patients. To expand our treatment abilities, many avenues remain open for exploration including neuroimaging for patient selection, neurointerventional...

Mri In Brain Tumors

The World Health Organization's GLOBOCAN 2000 study of cancer prevalence and mortality reported more than 17,000 new cases and nearly 13,000 deaths annually from primary CNS tumors in the United States alone (Parkin et al, 2001). These data do not include the prevalence of benign lesions or the estimated 100,000 cases of brain metastases from a non-CNS primary cancer. The classification and prognosis of intracranial neoplasms are based on histological features including cell type, degree of...

Mri In The Design Of Therapeutic Trials In Neurology

The disappointingly slow progress in developing effective therapies in neurological disease has led to a reevaluation of the strategies for clinical trials in stroke (thrombolytics, neuroprotectants), MS (immuno-suppressors, immunomodulators), and brain tumors (chemotherapy, radiation therapy, neurosurgery). As described previously, MS trials have used MRI as a tool for inclusion into studies as well as a surrogate parameter for secondary endpoint analyses. This section illustrates the...

Mri In Multiple Sclerosis

Multiple sclerosis MS is the most common demyelin-ating disorder and cause of neurological disability in young adults between 20 and 40 years old. MS has a higher prevalence in Caucasians from northern temperate climates Noseworthy, 2003 and females, and affects up to 350,000 individuals in the United States Anderson et al., 1992 . This chronic inflammatory disease of the central nervous system CNS is pathologically characterized by perivenous immune cell infiltration and myelin destruction,...

Mri In Acute Ischemic Stroke

Flair Mri Cerebral Infarction

Stroke is the third leading cause of death after myocardial infarction and cancer, the leading cause of permanent disability in western countries WHO Guidelines Subcommittee, 1999 , and the leading cause of disability-adjusted loss of independent life years. In addition to the tragic consequences for patients and their families, the socioeconomic impact of disabled stroke survivors is estimated to be between 35,000 and 50,000 per survivor, per year. In the face of our aging population, the...