Pathology and Histopathology

In Yabapox infection tumor cells which develop are characterized by the appearance of multinucleated cells, cytoplasmic granulation, nuclear enlargement, nucleolar hypertrophy and the formulation of numerous lipid vacuoles in the cytoplasm. Granular inclusions in the cytoplasm stain positively for DNA with acridine orange.

Tanapox virus infection is characterized by hypertrophy and thickening of the epithelial layers with swelling and ballooning of the deeper epithelial cells, which show vacuolation of cell nuclei and eosinophilic cytoplasmic inclusions.

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