The molecular biology of these viruses remains less studied as compared to that of VSV. Complementation studies and analysis of transcription initiation, termination and intergenic sequences of CHP and Piry virus indicate that the organization of the genome is similar to that of VSV (Fig. IB). The CHP virus has a single-stranded negative-sense RNA genome of approximately 11 kb long which encodes five structural proteins: the nucleocapsid protein N, the phospho-protein P, the matrix protein M, the glycoprotein G and the large protein L. The genome RNA is tightly encapsidated by the N protein and is associated with the RNA polymerase (a complex of L and P protein) to form an RNP complex. Transcription of the genome RNA by RNA polymerase gives rise to five dence and close intimacy between viruses and their host cells demonstrates adaptation through evolution by the parasite to take every advantage for self-propagation. The examples used to describe cell organization and metabolism in the context of virology should provide the reader with hints about the use that has been made of viruses as incisive probes of the living cell itself.
See also: Pathogenesis: Animal viruses, Plant viruses; Replication of viruses; Viral receptors; Virus-host cell interactions.
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