Humans are the natural host for HHV-6 and HHV-7. It was reported that some species of monkeys have antibody to HHV-6. HHV-6 and HHV-7 replicate most efficiently in vitro in activated primary T cells and T cell lines. HHV-6 and HHV-7 can be isolated by cocultivation of phytohemaglutinin-stimulated umbilical cord blood lymphocytes with peripheral blood mononuclear cells (PBMCs) from patients and saliva from individuals, respectively. The rate of HHV-6B isolation from PBMCs is nearly 100% on days 0-2 after the onset of exanthem subitum, and gradually decreases to zero during the convalescent phase.
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