The Tyl system has provided some insights into the roles of host-encoded proteins and RNAs on the retrotransposition process, and it is anticipated that many more remain to be discovered. A large number of host genes that play roles in Ty and host gene transcription have been uncovered genetically; these are called SPT genes because they were originally identified by mutations that suppressed the effect of Ty or LTR insertions. Although some of these affect Ty transcription, they do not affect the production of GAL/Ty mRNA. The development of sensitive assays for transposition of GAL/Tys in vivo has led to the identification of a number of host factors that are important for transposition at a post-transcriptional level; these are reviewed in Table 2.
See also: Coronaviruses (Coronaviridae); Retroviruses - type D (Retroviridae); Yeast RNA viruses
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