Printed In The United States Of America

To our sons: Florian and Paul Alessandro, Gianluca, and Fabio

Editors

J├╝rgen Fuchs Maurizio Podda

J.W. Goethe University, Frankfurt, Germany

Editorial Advisory Board

Marilena Aquino de Muro

CABI Bioscience, Egham, Surrey, U.K.

Deshratn Asthana

University of Miami, Miami, Florida, U.S.A. Ian Darby

RMIT University, Bundoora, Victoria, Australia Christian Drosten

Bernhard-Nocht Institute of Tropical Medicine, Hamburg, Germany

William E. Evans

St. Jude Children's Research Hospital, Memphis, Tennessee, U.S.A.

Yao-Shan Fan

University of Western Ontario, London, Ontario, Canada Michael Fero

Stanford University School of Medicine, Stanford, California, U.S.A.

Andras Guttman

Diversa Company, San Diego, California, U.S.A.

Walter Michael Halbmayer

Hospital Vienna-Lainz, Vienna, Austria

University of Liverpool, Liverpool, U.K. Alexander Haushofer

General Hospital of St. Poelten, St. Poelten, Austria

Frederick L. Kiechle

William Beaumont Hospital, Royal Oak, Michigan, U.S.A.

Fred Russell Kramer

Public Health Research Institute, Newark, New Jersey, U.S.A.

Larry J. Kricka

University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.

Vaidutis Kucinskas

Vilnius University, Vilnius, Lithuania

Pui-Yan Kwok

University of California, San Francisco, California, U.S.A.

Doron Lancet

Weizmann Institute of Science, Rehovot, Israel Mark Lawler

St. James Hospital and Trinity College, Dublin, Ireland Hans Lehrach

Max-Planck Institut fur Molekulare Genetik, Berlin, Germany

Edison Liu

National University of Singapore, Singapore Christine Mannhalter

University of Vienna Medical School, Vienna, Austria Bradley Popovich

Xenon Genetics, Inc., Burnaby, British Columbia, Canada

Jang B. Rampal

Beckman Coulter, Inc., Brea, California, U.S.A. Udo Reischl

University of Regensburg, Regensburg, Germany Nicholas J. Schork

University of California, San Diego, California, U.S.A. Nancy Templeton

Baylor College of Medicine, Houston, Texas, U.S.A.

Bimal Theophilus

Birmingham Children's Hospital NHS Trust, Birmingham, U.K.

Paul J. Van Diest

VU University Medical Center, Amsterdam, The Netherlands

Ishwar Chander Verma

Sir Ganga Ram Hospital, New Delhi, India

Akiyoshi Wada

RIKEN Genomic Sciences Center, Yokohama, Kanagawa, Japan

Victor W. Weedn

Carnegie Mellon University, Pittsburgh, Pennsylvania, U.S.A.

David S. Wilkinson

Virginia Commonwealth University, Richmond, Virginia, U.S.A.

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