Hepatobiliary Contrast Agents

Hepatobiliary contrast agents utilise hepatic excretion mechanisms to produce hepatocyte uptake and biliary excretion of paramagnetic ions by binding them to appropriate ligands. Two agents, Mangafo-dipir trisodium (Mn-DPDP, Teslascan) and Gado-benate dimeglumine (Gd-BOPTA, Multihance) are commercially available and a third, gadoxetic acid (Gd-EOB-DTPA, Eovist) is in phase III clinical trials (see Tables 14.1 and 14.2). Mangafodipir is the first manganese complex that has been used as contrast...

References

Aronen HJ, Perkio J (2002) Dynamic susceptibility contrast MRI of gliomas. Neuroimaging Clin N Am 12(4) 501-523 Baba Y, Furusawa M, Murakami R, Yokoyama T, Sakamoto Y, Nishimura R, Yamashita Y, Takahashi M, Ishikawa T (1997) Role of dynamic MRI in the evaluation of head and neck cancers treated with radiation therapy. Int J Radiat Oncol Biol Phys 37 783-787 Barbier EL, Lamalle L, Decorps M (2001) Methodology of brain perfusion imaging. J Magn Reson Imaging 13(4) 496-520 Barentsz JO, Engelbrecht...

MR Imaging of Bone and Soft Tissue Tumors

A broad consensus on diagnostic assessment of mus-culoskeletal tumors has emerged over the past decade. Radiographs, clinical data and MRI can narrow the differential diagnosis, and in some cases precisely diagnose the tumor type (Ma 1999 van der Woude et al. 1998a). However, biopsy is still required for accurate diagnosis of musculoskeletal lesions. Protocols for MR imaging and the intricacies of interpretation in diagnosing musculoskeletal lesions have been well described in recent reviews...