The main objectives were:
• To evaluate the role of preoperative radiotherapy.
• To compare two schedules of actinomycin D.
dose. The RFS was 54% and overall survival 82%. Eighty one patients received repeated actinomycin, in whom RFS was 58% and overall survival 86%, i.e. no significant difference.
The toxicities of the randomized arms with regard to other radiotherapy or chemotherapy were not given in detail.
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