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Note: Percentages may not add up to 100% because of rounding.

INSS: International Neuroblastoma Staging System and POG: Pediatric Oncology Group.

Table 17.58 Chemotherapy schema.

Induction CAE, cycles 1, 3, 5a

Cyclophosphamide (1 g/m2/day) on days 1 and 2 Doxorubicin (35 mg/m2/day as a 1-hour IV infusion) on day 1

Etoposide (30 mg/m2 as a bolus followed by 250 mg/m2/day as a continuous infusion) on days 2-5 PVP, cycles 2, 4, 6b Cisplatin (40 mg/m2/day) on days 1-5

Etoposide (200 mg/m2/day as a 1-hour IV infusion) on days 2-4 Consolidation Cycle 7

Carboplatin (700 mg/m2/day) on days 1, 3 and 5

Etoposide (500 mg/m2/day as a 6-hour IV infusion) on days 2, 4 and 6

Reinfusion of autologous marrow on day 7

CAE: cyclophosphamide, doxorubicin, and etoposide; IV: intravenous and PVP: cisplatin and etoposide. aPlanned length of each cycle of CAE = 17 days. bPlanned length of each cycle of PVP = 20 days.

there was a clear medical or surgical indication. Platelet transfusions were given when the platelet count was <20 X 109/l or if there was evidence of active bleeding.

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