IND: induction and LFT: liver function tests.

including seizures, tremors, facial palsy, hemiparesis, peripheral neuropathy and motor weakness. bSeptic shock including hypotension and/or requiring intubation. cProlonged partial thromboplastin time or hypofibrinogenemia.

dAspartate aminotransferase, alanine aminotransferase, or alkaline phosphatase >1.5 times the normal value, or total bilirubin >1.5 times the normal value.

The 3-year EFS rates for pegaspargase and native ASNase patients were 85% and 78%, respectively (NS) (Figure 14.19).


There were no differences in the incidence or the types of toxicities in between the two groups of patients (Table 14.26). No toxicity-related deaths were seen in either group.


It was concluded that patients treated with pegaspargase had more rapid clearance of lymphoblasts from the bone marrow on days 7 and 14 and more prolonged asparaginase activity than those treated with native asparaginase.

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