1

: etoposide (100 mg/m2/day IV over 1* X 5 days) - ifosfamide (1800 mg/m2/day IV over 1* X 5 days) ; With or without dexrazoxane (ICRF-187)

(IV bolus at 20 times [mg:mg] doxorubicin dose) ; With or without GM-CSF (5-15 ^g/kg/day subcutaneously)

Figure 17.26 Treatment schema. © American Society of Clinical Oncology (full reference on p. 518).

after November 1990, the dose was reduced to 5 |igm/kg/day based on the manufacturer's recommendations. For patients randomized to GMCSF, chemotherapy was withheld for at least 48 hours after their last injection of GMCSF.

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