Details of the study

Previously untreated children with standard risk ALL were enrolled on the study. Patients were stratified into prognostic risk groups according to the initial WBC count and age at diagnosis (Table 16.5).

Remission induction therapy consisted of either vincristine (VCR) 2 mg/m2/week (maximum 2 mg) X 4, or vindesine (VDS) 3mg/m2/week (maximum 3mg) X 4 plus prednisone (PDN) 60mg/m2/day (maximum 60 mg) X 4 weeks. Patients not in remission at 4 weeks were given an additional 2 weeks of treatment and were withdrawn from the study if remission was not achieved at 6 weeks.

Table 16.5 Stage of acute lymphoblastic leukaemia according to age and WBC count at diagnosis.

Age (Years)

Table 16.5 Stage of acute lymphoblastic leukaemia according to age and WBC count at diagnosis.

Age (Years)

WBC count (x109/l)

<1

1-<4

4-<6

6-<10

»10

«5

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