Details of the study

Eligible patients were less than 30 years of age with bone Ewing's sarcoma. Extraosseous Ewing's and primitive neuroectodermal tumor were excluded and no prior treatment was allowed.

The randomization method is not detailed, nor where this was done. Although analytical statistics are described, no anticipated patient number or predicted differences in outcome are detailed.

The protocol is as in Figure 3.6. All patients initially received a combination of cyclophosphamide 150mg/m2 orally for 7 days, combined with doxorubicin (Adriamycin) 35mg/m2, both drugs given every


Toxicity did not appear to be influenced by fractiona-tion. There were two patients who developed significant proctitis, although the radiation schedule is not detailed.

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