Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds

Segre Abstract Microbes colonizing and or infecting chronic wounds undoubtedly play a major and interactive role in impaired healing, especially in amplifying and perpetuating the host innate immune response. The development of molecular techniques to identify and quantify microbial organisms has revolutionized our view of the microbial world. These less-biased, high throughput methods greatly enable investigations regarding host-microbe interactions in the...

PTX3 in Pathogen Recognition and Inflammation

PTX3 interacts with a number of different pathogens including selected fungi, virus and bacteria (Fig. 1). A specific binding has been observed to Aspergillus fumigatus conidia, zymosan, Paracoccidioides brasiliensis, selected Gram positive and Gram negative bacteria, including Staphyloccocus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Streptococcus pneumoniae and Neisseria menin-gitides and with human and murine cytomegalovirus (CMV) and H3N2 influenza virus (Garlanda et al. 2002...

List of Contributors

Thomas Areschoug Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, S lvegatan 23, 22362 Lund, Sweden e-mail Thomas.Areschoug med.lu.se Jennie B ck Dept of Immunology, Genetics and Pathology IGP , Rudbeck Laboratory C5 3, Uppsala University, SE-751 85 Uppsala, Sweden e-mail jennie.back igp.uu.se O. L. Brekke Department of Laboratory Medicine, Research Laboratory, Nordland Hospital, Bod0, Norway Institute of Medical Biology, University of Troms0, Troms0, Norway...