Info

8 MASP1/3KO mice were affected to infection of influenza

A (H1N1) virus 100

9 Conclusion 102

10 Acknowledgement 102 References 102

9. VIRAL HEPARIN-BINDING COMPLEMENT INHIBITORS - A

RECURRING THEME 105

Anna M. Blom, Linda Mark and O. Brad Spiller

1 Introduction 105

2 Complement Activation by Pathogens 106

3 Consequence of Complement Activation for Viruses 108

4 Regulation of Complement Activation 109

5 Viral Complement Inhibitors Homologous to RCA Proteins 109

5.1 Orthopoxviruses 109

5.2 Gammaherpesviruses 110

5.3 Alphaherpesviruses 112

6 Introduction to Heparin 113

6.1 Heparin Binding to Host Complement Inhibitors 114

6.2 Heparin binding to Viral Complement Inhibitors with CCP

Domains 115

6.3 Heparin binding by HSV Glycoprotein C 115

6.4 Uncharacterized Heparin Binding by Other RCA Host Proteins 118

7 Conclusion 119

8 Acknowledgements 120 References 120

10. C3a RECEPTORS SIGNALING IN MAST CELLS 126

Asifa K. Zaidi and Hydar Ali

1 Introduction 126

2 C3a Generation and Its Effect on Allergen Sensitization 127

2.1 Role of Mast Cells and C3aR in the Effector Phase of Asthma 128

3 C3aR Signaling in Mast Cells 129

3.1 C3aR Desensitization 130

3.2 ß-arrestin as a Regulator of Down-Stream Signaling Pathway 131

3.3 Role of PDZ domain proteins on C3aR functions in mast cells 132

4 Conclusion 134

5 Acknowledgements 135 References 135

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