Spironolactone Induced Gynecomastia

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The pathophysiology of gynecomastia after spironolactone administration has been carefully studied in man. As noted above, spironolactone induces gynecomastia (and other antiandrogenic effects) principally by binding to cytosolic





FIGURE 2. Active androgens and more specifically 5a-dihydrotestosterone (DHT) interact with the androgen receptor (R) in target tissues to form hormone receptor complexes which activate protein synthesis. Low (50-75 mg) or high (200-400) doses of spironolactone interfere with DHT binding with its receptor to form inactive complexes at the nuclear level. From Tremblay.

androgen receptors. Subsequently, in patients who develop gynecomastia, blood testosterone levels decrease and blood estradiol levels increase. These changes come about by increases in metabolic clearance rate of testosterone as well as an increase in peripheral conversion to estradiol. Consequently, excessive stimulation of breast tissue as a result of an imbalance between estrogen and testosterone in the body leads to increased ductal proliferation and tender breast enlargement in males. Discontinuation of the drug results in slow reversal of this process sometimes requiring several months for complete normalization of breast size.

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Using Exercise To Get Rid Of Man Boobs

Using Exercise To Get Rid Of Man Boobs

In this guide, youll learn just what kinds of exercises you can use to get rid of man boobs forever. It includes two different types of exercises those designed to burn body fat, helping you lose excess weight all over your body and targeted chest exercises which will shrink your man boobs until you have a masculine, sexy chest.

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