Hypo and Hypernatremia

Hyponatremia is an important adverse effect of thiazide diuretics, especially if long-acting like chlorthalidone; hypernatremia is more commonly seen with loop diuretics causing dehydration. Thiazide diuretics induce the excretion of more sodium than water, whereas the impairment of the cortico-medullary osmotic gradient by loop diuretics leads to a larger excretion of water than sodium—loop diuretics are often used in the treatment of hyponatremia. Hyponatremia is also more likely to occur in hypokalemic patients.

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