Trophoblast turnover [122123

Like every epithelium, the villous trophoblast displays a continuous turnover comprising: 1 proliferation of cytotrophoblast stem cells,

2 differentiation of post-proliferative daughter cells (23 days),

3 syncytial fusion of these cells with the overlying syncy-tiotrophoblast,

4 further differentiation and maturation within the syn-cytiotrophoblast (3-4 weeks),

5 aging and late apoptosis at specific sites of the syncy-tiotrophoblast, and finally

6 packing of old material into syncytial knots and extrusion of membrane-sealed corpuscles into the maternal circulation.

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Once your pregnancy is over and done with, your baby is happily in your arms, and youre headed back home from the hospital, youll begin to realize that things have only just begun. Over the next few days, weeks, and months, youre going to increasingly notice that your entire life has changed in more ways than you could ever imagine.

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