Throughout gestation, syncytial knots are released into the maternal circulation [21-27] and are mostly lodged in the capillary bed of the lung. Hence, they can be found in uterine vein blood but not in arterial blood of a pregnant woman. It has been estimated that in late gestation up to 150,000 such corpuscles or 2-3 g of trophoblast material enter the maternal circulation each day [1,21].
Current knowledge places the multinucleated syncy-tial knots as products generated by apoptotic mechanisms . As such, they are surrounded by a tightly sealed plasma membrane not releasing any content into the maternal blood. Hence, induction of an inflammatory response of the mother is not a normal feature of pregnancy. However, during placental pathologies with a disturbed trophoblast turnover such as pre-eclampsia the release of syncytiotrophoblast material is altered to a more non-apoptotic release. This necrotic or aponecrotic release of material could easily induce the endothelial damage typical of pre-eclampsia [21-23,25-27].
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Once your pregnancy is over and done with, your baby is happily in your arms, and youre headed back home from the hospital, youll begin to realize that things have only just begun. Over the next few days, weeks, and months, youre going to increasingly notice that your entire life has changed in more ways than you could ever imagine.