Calcium homeostasis changes markedly [18,19]. Maternal total plasma calcium concentration falls, because albumin concentration falls, but unbound ionized calcium concentration is unchanged. Synthesis of 1,25 dihydrox-ycholecalciferol increases, promoting enhanced gastrointestinal calcium absorption. Parathyroid hormone (PTH) regulates the synthesis of 1,25 dihydroxyvitamin D in the proximal convoluted tubule. There is a fall in intact PTH during pregnancy but a doubling of 1,25 dihydroxyvitamin D; placentally synthesized PTH-related protein is also present in the maternal circulation.
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The first trimester is very important for the mother and the baby. For most women it is common to find out about their pregnancy after they have missed their menstrual cycle. Since, not all women note their menstrual cycle and dates of intercourse, it may cause slight confusion about the exact date of conception. That is why most women find out that they are pregnant only after one month of pregnancy.