In pre-eclampsia, there is an almost five fold increase in fetal DNA in the maternal circulation compared with controls [28,29]. In women destined to develop pre-eclampsia, fetal DNA is noted to be elevated before the disease becomes symptomatic . A two stage rise is noted in these patients. Raised levels of fetal DNA were detected as early as 17 weeks gestation followed by a second rise approximately 3 weeks before the onset of symptoms . This phenomenon may allow both screening for the disease, as well as indicating impending pre-eclampsia. However, this test is not yet in routine clinical practice as it requires further validation.
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The first trimester is very important for the mother and the baby. For most women it is common to find out about their pregnancy after they have missed their menstrual cycle. Since, not all women note their menstrual cycle and dates of intercourse, it may cause slight confusion about the exact date of conception. That is why most women find out that they are pregnant only after one month of pregnancy.