The management of PMS has, over the past few years, become increasingly easy if somewhat more invasive than these measures. First, it should be stated that there is overwhelming evidence that progesterone pessaries and oral progestagens are entirely ineffective . Ironically, these are the only drugs in the United Kingdom and Europe which have a pharmaceutical licence for PMS. Remember that the proposed aetiology of PMS is that normal post-ovulatory progesterone gives rise to symptoms only in women who have increased sensitivity to progesterone and this is likely to be due to serotonin 'deficiency'. Broadly speaking, then, treatment should be achievable either by suppressing ovulation and the endocrine cycle either pharmacologically or by surgery or it may be achieved by altering the sensitivity to progesterone by elevating serotonin levels.
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The first trimester is very important for the mother and the baby. For most women it is common to find out about their pregnancy after they have missed their menstrual cycle. Since, not all women note their menstrual cycle and dates of intercourse, it may cause slight confusion about the exact date of conception. That is why most women find out that they are pregnant only after one month of pregnancy.