Metabolism and Excretion of Toxicants

Leupeptin Plant

The amount of free plasma toxicant is a function of the toxicant's absorption, distribution, and elimination (Figure 9.1). In Chapter 8, a variety of factors that govern the absorption of toxicants in the gastrointestinal (GI) tract were discussed. This chapter focuses on factors that influence distribution and elimination of toxicants. Toxicants and other foreign compounds (xenobiotics) undergo metabolic transformation in the body. In many situations, the rate of metabolism is the primary...