Heart Disease

A high zinc copper ratio has been linked to hypercholesterolemia 103 . Thus, by virtue of its ability to bind these divalent cations and potentially alter their balance and availability 7,8 , PA may also affect serum cholesterol levels Figure 14.3(C) . In fact, some foods rich in PA, such as bengal gram beans, have been shown to have hypocholesterolemic effects 104 . Although cereal fiber has been associated with decreased coronary heart disease risk 105 and wheat fiber left over from the...

Conclusions

Through the mid 1980s, phytate was regarded strictly as a dietary inhibitor of mineral absorption. More recently, studies indicate that phytic acid is a natural antioxidant important for seed viability. Evidence also indicates that the inhibitory effects of phytate on mineral absorption are not seen in varied diets containing animal protein. Phytate may actually be beneficial as a dietary an-tioxidant in an animal protein diet. There may be nutritional advantages, or at least no disadvantage,...

Introduction

For several decades, concerns have been raised about the role of phytic acid in reducing mineral bioavailability. Because dietary phytic acid is a ubiquitous plant constituent present in nuts, cereals, legumes, and oilseeds, current trends in food choices merit a reexamination of this issue. Recommendations for increasing consumption of cereals and grains as the foundation of the food guide pyramid by the U.S. Dietary Guidelines Committee has prompted one such trend. A second trend is that...

References

Shamsuddin, A.M., Vucenik, I. and Cole, K.E. 1997. IP6 a novel anti-cancer agent. Life Sci. 61 343-354. 2. Graf, E. and Eaton, J.W. 1990. Antioxidant functions of phytic acid. Free Radic. Biol. Med. 8 61-69. 3. Vohra, P., Gray, G.A. and Kratzer, F.H. 1965. Phytic acid-metal complexes. Proc. Soc. Exp. Biol. Med. 120 447-449. 4. Graf, E., Mahoney, J.R., Bryant, R.G. and Eaton, J.W. 1984. Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. J. Biol....

Protection From Vitamin E And Selenium Deficiency By Phytate

We conducted an experiment to test whether the concentration and the form of inositol phosphates were important factors in determining whether phy-tate would exhibit antioxidant or pro-oxidant effects in vivo. Our lab has used a model of chronic oxidative stress induced by deficiency in vitamin E and selenium to study the adaptive responses invoked to protect rats from damage. Deficiency of these two nutrients leads to a gradual increase in oxidative stress, indicated by greater tissue...