Cromoglycate

Sodium cromoglycate is a sodium salt of chromone-2-carboxylic acid. It inhibits the release of mediators from mast cells and basophils, although this does not fully explain its effectiveness in IgE-mediated allergic diseases. Only 1% of the orally administered dose is absorbed from the gastrointestinal tract.

Oral sodium cromoglycate may be useful in some patients with multiple food allergies.12 It is a less effective but safer alternative to steroids in the management of chronic food allergy not responding adequately to food allergen avoidance. However, it should not be used in place of allergen avoidance. Acute symptoms such as bronchospasm, rash, nausea and diarrhoea respond better than do chronic food-related diseases such as atopic eczema. Side effects are minimal, although nausea, rashes and joint pain have been reported.

Table 5.5 Adverse effects associated with glucocorticoid and mineralocorticoid activity of corticosteroids

Activity Side effects

Mineralocorticoid Hypertension, sodium and water retention, potassium loss and adrenal suppression

Glucocorticoid Diabetes, osteoporosis, psychosis, proximal myopathy, peptic ulceration, cataract and skin atrophy, hirsutism, reduction in ability to fight infection

Food Allergies

Food Allergies

Peanuts can leave you breathless. Cat dander can lead to itchy eyes, a stuffy nose, coughing and sneezing. And most of us have suffered through those seasonal allergies with horrible pollen counts. Learn more...

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