Xanthine Derivatives

Mechanism of action of drugs for asthma therapy. Schering Plough), which targeted airway receptors and exhibited reduced systemic side effects. A series of short-acting agents following the same general structure (shown in Figure 16.3A) were developed, including terbutaline (AstraZeneca) and fenoterol (Boehringer Ingelheim). As the chemistry of these drugs came to be understood, they were modified to achieve several things, including local metabolism to an active agent, increased...

Prodrugs And Intellectual Property Rightstwo Court Cases

The primary purpose for developing prodrugs is, of course, not to circumvent intellectual property rights but to obviate certain disadvantages that may have precluded an active agent from being used in clinical applications. Therefore, if undesirable properties of a drug molecule cannot be overcome by conventional changes in the pharmaceutical formulation or route of administration, the method of choice is to use one of the prodrug approaches discussed above. The parent drug usually came first...