GH Receptor Antagonist Therapy

GH binds to its hepatic receptors, inducing dimerization, which signals a cascade of molecular events culminating in IGF-1 generation (114). Pegvisomant, a genetically engineered GH analog, binds to the GH receptor (Fig. 9) and prevents functional GH receptor dimerization, thereby preventing GH signal transduction and subsequent IGF-1 generation (115-117). This novel mechanism of action inhibits peripheral GH action, rather than decreasing GH secretion. Pegvisomant administered by daily subcutaneous injection normalizes IGF-1 levels in more than 90% of patients, with decreased fatigue, soft tissue swelling and perspiration (117). Pegvisomant has not yet been approved by the Food and Drug Administration.

Was this article helpful?

0 0
Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook

Post a comment