Info

THC, tetrahydrocannabinol; BE, benzoylecgonine; PCP, phencyclidine; 6-MAM; 6-monoacetylmorphine; MDMA, 3, 4-methylenedioxymethamphetamine; MDEA, 3,4 methylenedioxyethylamphetamine; MDA, methylenedioxyamphetamine.

THC, tetrahydrocannabinol; BE, benzoylecgonine; PCP, phencyclidine; 6-MAM; 6-monoacetylmorphine; MDMA, 3, 4-methylenedioxymethamphetamine; MDEA, 3,4 methylenedioxyethylamphetamine; MDA, methylenedioxyamphetamine.

submitted to a reference laboratory over a 12-mo period (11). The results for the common five-panel DOA were compared to urine results within the same laboratory and also to the Quest laboratory data base for urine testing. Tables 6-8 show that, overall, oral-fluid results obtained by the Intercept system are comparable to those found with urine testing. This is somewhat surprising considering the shorter window of detection of drugs in oral fluid. Possible reasons for these results include broad use of urine adulterants masking many positives or the fact that many individuals abusing drugs have ingested substances close to the time of their sample collection. In either case, it suggests that oral fluid is a good alternative to urine testing for routine pre-employment testing.

7. Conclusions

DOA testing has become routine in many aspects of life. An established algorithm, which appears to be universally accepted, utilizes antibody-based tests

Table 5

Typical Limit of Quantitation (LOQ)/Limit of Detection (LOD) of Various Drugs of Abuse Obtained by GC-MS-MS Using Intercept® Diluent

Table 5

Typical Limit of Quantitation (LOQ)/Limit of Detection (LOD) of Various Drugs of Abuse Obtained by GC-MS-MS Using Intercept® Diluent

Target Analyte

LOQ (ng/mL)

LOD (ng/mL)

Amphetamine

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