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GC-MS, gas chromatography-mass spectrometry; COC, cocaine; MET, methamphetamines; AMP, amphetamines; OPI, opiates; THC, tetrahydrocannabinol; PCP, phencyclidine.

GC-MS, gas chromatography-mass spectrometry; COC, cocaine; MET, methamphetamines; AMP, amphetamines; OPI, opiates; THC, tetrahydrocannabinol; PCP, phencyclidine.

confirmation test. The results as shown in Table 5 suggest that the Oratect device can detect the presence of codeine up to 6 h after the administration of a single 10-mg dose of codeine. It also confirms that GC-MS confirmatory testing using oral fluids collected with the Oratect device is a viable procedure and provides a correlation coefficient of 0.96 with the Intercept method.

4. Extension of Oratect Opiate Detection Window

When the Oratect opiate C.O. concentration was lowered to 10 ng/mL (6), the results (as shown in Table 6) suggested that the detection window can be extended twofold to 12 h. In this experiment, five healthy, normal subjects were each administered one dose of Prometh. Oratect test (with 10 ng/mL opiate C.O.) and Monitect urine drug screen were undertaken at 1,6, 8, 10, 14, and 16 h after the administration of the dose.

5. Detection of THC Over Time

Two men (subjects A and B) and one woman (subject C) were tested for THC after each of them smoked a single marijuana cigarette. Oratect drug screens and Intercept collections were performed at half-hour intervals. Both the Oratect collection pads and the Intecept devices were sent to Scientific Testing Laboratory for GC-MS analysis. The results as shown in Table 7 suggest that the Oratect can detect the presence of THC up to 2 h after use. Moreover, the Oractect GC-MS results correlate well with the Intercept GC-MS data.

6. Drug Interference Study

Drugs and metabolites that may potentially cross-react with the Oratect test were evaluated (8), and the results are shown in Tables 8 and 9. Each

Correlation of Oratect® Opiate Test With Oral-Fluid Gas Chromatography (GC)-Mass Spectrometry (MS) and Urine Drug Screen

1 h 4 h 6 h

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