Adulteration will be a continuing problem for the drug-testing industry and scientific community. Manufacturers of adulterants have successfully developed innovative means and chemical formulas to mask positive drug results. Although banning the sales of these adulterants may prevent their availability in some areas, the Internet would always ensure their availability. Both governmental agencies and adulteration test manufacturers should constantly update their test criteria to combat the continuous formulation change strategy of the adulterant companies. Laboratory reagents and on-site dipsticks have proven to be effective in detecting their presence in adulterated urine specimens. For convenience, manufacturers of drug screens have started to produce devices that test for drug and screen for adulteration simultaneously. In this way, the integrity of the specimen is assured while the drug screen is being performed. Examples include Monitect PC11A, ToxCup® PT15A, and QuickTox® 51A from Branan Medical Corporation. However, the self-destructive nature of the new generation of adulterants suggests that testing for them should be performed as soon after collection as possible and preferably on-site. Presently, owing to economic pressure, adulteration testing is not always performed on all specimens. In these cases, false negatives may result and the value of drug testing is compromised.
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