Controlled Study With MDMA

In this study, two male volunteers were given a single dose of 100 mg MDMA. MDMA was administered orally with 100 mL of tap water (two capsules each time). Subjects were swabbed in their armpit for 10 s at time zero (0, predose) and at 2, 6, 8, 12, 24, 36, and 48 h after MDMA administration. The sweat sample was collected with the wiping fleece of the test kit for amphetamines. The wiping fleece was moistened with tap water. The analysis of the sweat sample was performed in accordance with the instructions for use (3). Blood samples from the volunteers were also taken at 0 (predose), 2, 4, 6, 8, 12, and 24 h after drug administration. Blood was immediately centrifuged, and plasma was stored at -20°C until analysis. The plasma was analyzed for the presence of MDMA by GC-MS (6).

The major experimental findings with respect to the performance of Drug-wipe are summarized in Fig. 7. The concentration curve shown in the diagram is the mean plasma concentration of both volunteers. The individual curves are only slightly different, and the data are published in Pacifici et al. (6). The maximum mean value was reached after 4 h and was approx 150 ng/mL. Drug-

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