Plant cell tissue culture for the production of active compounds

For plant compounds one can consider several possibilities of biotechnological production plant cell tissue cultures, transgenic plants or plant cells, transgenic microorganisms and isolated enzymes. For transgenic systems it is necessary to know the pathway of production involved and have the genes available. Isolated enzymes can be used only for bioconversions, that is going from a precursor to the next product. One application of PCTC is to provide an alternative method for producing food...

Concluding remarks

Our diet contains a host of secondary metabolites which can interact with important pharmacological targets, and for which biological activity can be demonstrated in in vitro and in vivo assays. The role of these interactions for human homeostasis is unknown, and the translation of dietary constituents into pharmaceutical leads is undoubtedly fraught with difficulties. Nevertheless, it is not unconceivable that in the near future progress in biomedical sciences will put us in the position to...

Info

Daniell, H., Streatfield, S.J. and Wycoff, K. (2001) Medical molecular farming production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci., 6, 219-226. De Jung, T.J. (1995) Why fast-growing plants do not bother about defence. Oikos, 74, 545-548. De Luca, V. and Laflamme, P. (2001) The expanding universe of alkaloid biosynthesis. Curr. Opin. Plant Btol., 4, 225-233. De Luca, V. and St Pierre, B. (2000) The cell and developmental biology of alkaloid biosynthesis....

V

Amount of red yeast rice sufficient to meet its sales projections. In February 1999, the FDA's ban on the import of red yeast rice was lifted, but it appealed the decision, and the saga is still going on (Israelsen, 1999). At the same time, Merck, which manufactures lovastatin, and Bristol-Myers Squibb, which produces pravastatin, a successful analogue, requested permission to sell to the general public their pharmaceutical-grade products at doses comparable to those found in the red yeast rice...

Introduction

Dietary supplements are in widespread use in the United States (Eisenberg et al., 1993, 1998 Kessler et al., 2001). This use continues to grow as more people, particularly the baby-boomers, become concerned about their access to health care, and the quality of that care, and seek complementary and alternative medical practices (Eisenberg et al., 1998 Foster et al., 2000 Kessler et al., 2001 Rainey and Cason, 2001). With the increasing advent of food that is heavily synthetic and influenced by...

Definitions of dietary supplements

The DSHEA defines dietary supplements for regulatory purpose within the United States. The Office of Dietary Supplements at the NIH needed to implement research priorities using this definition and yet in some manner group the wide array of supplement ingredients available in the marketplace into more manageable categories. A definition was needed that also could be interpreted more readily in terms of research projects. An operating definition was requested in meetings with the NIH Institute...

Dietary supplements of plant origin

In order to survive, plants have developed sophisticated mechanisms including an elaborate chemical arsenal of toxic substances, such as terpenes and alkaloids, that inhibit the growth of other plants and make them unattractive to predators da Rocha et al., 2001 see also chapter by Maffei . The ability of plants to produce bioactive compounds has been exploited by humans for thousands of years, and plant extracts and plant parts have been used since ancient times to cure various diseases. The...