Arises from squamous epithelial cells of the glans penis or inner lining of prepuce; multiple contributing factors including chronic irritation (urine, smegma), inflammation (heat, friction, maceration) and infection (herpes simplex virus infection, human papillomavirus infection)
Minimally raised, erythematous plaques, which may be smooth, velvety, scaly, crusted, or verrucous; ulceration or distinct papillomatous papules suggest progression to invasive squamous cell carci-
Carcinoma in situ of the penis Definition
Precancerous epithelial proliferation of the penis, almost always occuring in uncircum-cised men
Erythroplasia of Queyrat. Ill-defined, scaly, eroded plaque of the glans penis
Fluorouracil, topical; destruction by liquid nitrogen cryotherapy or electrodesiccation and curettage
Fitzgerald DA (1998) Cancer precursors. Seminars in Cutaneous Medicine & Surgery 17(2):108-113
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