Erythroplasia of Queyrat

Pathogenesis

Arises from squamous epithelial cells of the glans penis or inner lining of prepuce; multiple contributing factors including chronic irritation (urine, smegma), inflammation (heat, friction, maceration) and infection (herpes simplex virus infection, human papillomavirus infection)

Clinical manifestation

Minimally raised, erythematous plaques, which may be smooth, velvety, scaly, crusted, or verrucous; ulceration or distinct papillomatous papules suggest progression to invasive squamous cell carci-

Synonym(s)

Carcinoma in situ of the penis Definition

Precancerous epithelial proliferation of the penis, almost always occuring in uncircum-cised men

Erythroplasia Queyrat

Erythroplasia of Queyrat. Ill-defined, scaly, eroded plaque of the glans penis

Differential diagnosis

Balanitis of Zoon; balanitis xerotica obliter-ans; candidiasis; contact dermatitis; squa-mous cell carcinoma; fixed drug reaction; psoriasis; lichen planus

Therapy

Fluorouracil, topical; destruction by liquid nitrogen cryotherapy or electrodesiccation and curettage

References

Fitzgerald DA (1998) Cancer precursors. Seminars in Cutaneous Medicine & Surgery 17(2):108-113

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