Foods

Red wine Fresh grapes Raisins

Mefenamic acid

Meprobamate

Methaqualone

Metronidazole

Naproxen

Nystatin

Paracetamol

Penicillins

P. aminosalicylic acid

Phenacetin

Phenolphthalein

Pipemidic acid

Piroxicam

Prochlorperazine

Pyrazolon derivatives

Quinine derivatives

Quinidine

Sulfonamides

Sulindac

Tetracyclines

Tinidazole

Trimethoprim

Strawberries Cheese crisps Saccharin

* Drugs most frequently implicated.

t Once found in most OTC laxative preparations. Banned for use in the United States.

Self-Medication

Periodic self-treatment with prescription or OTC medications is almost always the underlying cause of a fixed drug reaction.

Supplemental Review From General History

An intensive and repetitive review of all medication used must be undertaken. The questions should focus on medication taken intermittently. All prescription medications,

OTC drugs, foods, and nutritional substances should be included. Patients often do not think of some of these as medications or are embarrassed to admit to their use. When a fixed drug reaction is strongly suspected and the drug history is not productive, a general review of systems may uncover conditions that require periodic medication use. Additional history may then allow a deductive approach to the answer.

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