Nicotine

CAS Registry Number [55-11-5]

Nicotine is an alkaloid found in tobacco, and is responsible for its pharmacological effects and addiction. Contact dermatitis from nicotine, considered as rare, has been more frequent since its use in transdermal systems. Irritant dermatitis is mainly encountered, as contact urticaria seems to be rare. Allergic contact dermatitis, sometimes generalized, has been reported, with positive patch testing to nicotine base (10% ethanol or petrolatum). No consequences have been reported in patients who start smoking again after skin sensitization.

Suggested Reading

Bircher AJ, Howald H, Rufli T (1991) Adverse skin reactions to nicotine in a transdermal therapeutic system. Contact Dermatitis 25: 230-236 Vincenzi C, Tosti A, Cirone M, Guarrera M, Cusano F (1993) Allergic contact dermatitis from transdermal nicotine systems. Contact Dermatitis 29:104-105

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