Additional Characteristics Of Capecitabine

Capecitabine and 5'-DFUR given orally were highly antimetastatic in a spontaneous metastasis model with Lewis lung carcinoma (37), a highly metastatic mouse tumor, when given in the neoadjuvant setting. These drugs were only slightly more effective against the inoculated primary tumor than 5-FU in this tumor model (9), whereas they were much more effective against spontaneous metastasis compared to 5-FU. Capecitabine, 5'-DFUR, and 5-FU all inhibited the formation of metastases at, respectively,...

Combined Locoregional And Systemic Chemotherapy

The rationale for combining locoregional and systemic chemotherapy in advanced col-orectal cancer with metastases to the liver only is based on the following issues 1. Locoregional chemotherapy has a well-defined activity in these patients and is possibly superior, as reported above, to systemic treatment (at least when traditional agents are administered intravenously). 2. The two therapeutic modalities have nonoverlapping side-effects (liver toxicity for intraarterial therapy, chiefly when...

References

Molecular bases for circadian clocks. Cell 1999 96(2) 271-290. 2. Shearman LP, Sriram S, Weaver DR, et al. Interacting molecular loops in the mammalian circadian clock. Science 2000 288 1013-1019. 3. Cermakian N, Sassone-Corsi P. Multilevel regulation of the circadian clock. Nature Rev Mol Cell Biol 2000 1 59-67. 4. Lowrey PL, Takahashi JS. Genetics of the mammalian circadian system photic entrainment, circadian pacemaker mechanisms and posttranslational regulation. Ann Rev Genetics...

Clinical Pharmacology Trials

UFT in a dose range of 100-400 mg results in linear plasma exposures of tegafur, uracil, and 5-FU. In order to assess the pharmacokinetics of single- and continuous-dose UFT, patients with metastatic colorectal cancer initally received a single dose of UFT at either 100, 200, or 400 mg, accompanied by LV 25 mg orally, followed, after 7 d of rest, by treatment with UFT 300 mg m2 plus LV 75 mg d. After single-dosing, the plasma concentrations of tegafur, 5-FU, and uracil rose rapidly, reaching...

Future Development Of Uft Plus Lv Therapy

Anticancer drugs are often used in combination not only to improve therapeutic efficacy, but also to slow the development of resistance to the agents. UFT is being studied in combination with other new cytotoxic drugs and or radiotherapy in order to improve the effectiveness of the treatment of metastatic CRC. Irinotecan CPT-11, Campto, Camptosar has been used in the treatment of metastatic CRC 19 with response rates of 14-31 23 . Irinotecan exerts its anticancer action by inhibiting...

Clinical Chronopharmacology

Rhythm in 5-FU Pharmacokinetics 5-FU 15 mg kg, e.g., approx 600 mg m2 was injected intravenously bolus at 01 00, 07 00, 13 00 or 19 00 h to 28 patients with metastatic gastrointestinal cancer in a randomized sequence, each injection being separated by 96 h from the next one. Both plasma pharmacokinetics and hematologic toxicity were assessed. 5-FU dosing at 01 00 h resulted in the longest half-life, in the largest VdSS and AUC, and in the lowest clearance CIB , as well as in the least...