How Does Progesterone Work

During your regular monthly cycle, progesterone is made by the ovarian follicle (called the corpus luteum) just after ovulation. This progesterone circulates through your bloodstream and helps to stabilize and maintain your uterine lining (endome-trium) so that it will be ready for a fertilized egg. If pregnancy occurs, progesterone is required to maintain the pregnancy. If you don't become pregnant during that cycle, the progesterone levels decrease and eventually cause the lining of your uterus to shed, resulting in menstrual bleeding. Progesterone plays an important role in your menstrual cycle, hormonal balance, and ovulation. Supplemental progesterone can be helpful if you suffer from these fertility conditions.

During an assisted reproductive technology, progesterone supplementation may also be given. In this case, supplemental progesterone is given to mimic and reinforce your body's naturally occurring progesterone. The purpose is to thicken and prepare the uterine lining for the fertilized egg(s) and help to maintain the pregnancy.

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