Note that the dried rhizome of Cimicifuga racemosa (British Pharmaceutical Codex, 1934; black cohosh) has been used as a bitter and mild expectorant in the form of a liquid alcoholic extract (1 in 1; dose: 0.3-2 mL) and is sold as alternative remedy for the treatment of menopausal syndrome at dose of 40-80 mg/day. The active constituents of black cohosh, and, therefore, the precise molecular mechanism of action involved in the climacteric property of Cimicifuga racemosa, are still unknown. The most recent data suggest that the plant is not estrogenic sensu stricto (126).

Jarry et al. showed that the extract of Cimicifuga racemosa contains some agents that bind to an unknown estrogen-binding site in the endometrium and dopamine D2 receptors (127). It will be interesting to learn whether further study on Cimicifuga foetida and the Cimicifuga species disclose any dopaminergic principles, and whether these are isoquinoline alkaloids. What is the interrelationship between estrogens and dopamine? Can we expect estrogenic compounds as antiparkinson agents?



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