The plant is known elaborate series of aporphines alkaloids such as glaucine and boldine. Glaucine is cytotoxic against HeLa cells with an IC50 value of 8.2 (iM thought a cellular mechanism which involves DNA intercalation (110). If the cytotoxic potentials of Lau-raceous aporphines are well-known, much less evidence is available on their dopaminergic potentials. Hegde et al. made the interesting observation that 5-hydroxy-indoline, a glycosylated tetrahydroisoquinoline analog SCH 71450 from the fruit of Phoebe chekian-gensis, showed dopaminergic effects, in receptor ligand-binding assay for D4 receptor (111) binding displacement.
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